Genomic Medicine

Genomic Medicine

SR NOTESTTEST COMPONENTSMETHODSPECIMEN/TRANSPORTTATCLINICAL APPLICATIONS
1Broad Range Bacterial (16SRNA) IdentificationA broad range of infectious organismsNext-Generation SequencingCulture colonies preferred/Blood culture/Body fluids15 daysidentify the rare species in CSF and or sample proceed for culture to identify the bacterial spp.
2HBV (Hepatitis B) Analysis-COBAS TAQMANQuantitative detection of Hepatitis B viral load by COBAS TaqmanRT-PCR TAQMANPlasma, EDTA whole blood (3ml)1 dayThis test is intended for use as an aid in the management of patients with chronic HBV infection undergoing antiviral therapy. The test can be used to measure HBV DNA levels at baseline and during treatment to aid in assessing response to treatment. The results from this test must be interpreted within the context of all relevant clinical and laboratory finding.
3HBV Drug Resistance and GenotypingMutation in RT region of HBVSanger SequencingPlasma, EDTA whole blood (3ml)7 daysIn patients with confirmed treatment adherence who exhibit virologic breakthrough or rebound, resistance testing can be used to confirm the presence of mutations and therefore guide selection of subsequent therapy.
4HBV (Hepatitis B) GenotypingGenotyping of Hepatitis B virusSanger SequencingPlasma, EDTA whole blood (3ml)4 daysHBV genotypes A–H are classified according to sequence variations in the HBV “S” gene and have distinct geographic distributions. Genotype analysis may have prognostic value.
5HBV Basal core/precore mutation analysisMutation detection in pre-C and BCP region of HBVSanger SequencingPlasma, EDTA whole blood (3ml)7 daysIn patients with confirmed treatment adherence who exhibit virologic breakthrough or rebound, resistance testing can be used to confirm the presence of mutations and therefore guide selection of subsequent therapy.
6HCV (Hepatitis C) Qualitative DetectionQualitative detection of Hepatitis C virusReal Time PCRPlasma, EDTA whole blood (3ml)1 dayThis test is intended for use in conjunction with clinical presentation and other laboratory markers of disease progress for the clinical management of HCV infected patients.
7HCV (Hepatitis C) Quantitative AnalysisQuantitative detection of Hepatitis C viral loadReal Time PCRPlasma, EDTA whole blood (3ml)1 dayThis test is intended for use in conjunction with clinical presentation and other laboratory markers of disease progress for the clinical management of HCV infected patients. The test can be used to monitor the HCV RNA level during the course of antiretroviral treatment.
8HCV (Hepatitis C) Analysis- COBAS TAQMANQuantitative detection of Hepatitis C viral load by COBAS TaqmanRT-PCR TAQMANPlasma, EDTA whole blood (3ml)1 dayThis test is intended for use in conjunction with clinical presentation and other laboratory markers of disease progress for the clinical management of HCV infected patients. The test can be used to monitor the HCV RNA level during the course of antiretroviral treatment.
9HCV (Hepatitis C) GenotypingGenotyping of Hepatitis C virusSanger SequencingPlasma, EDTA whole blood (3ml)4 daysDetermining hepatitis C virus genotype (1 to 5) to guide antiviral therapy in patients with chronic hepatitis C
10HIV-1 (Human Immuno Deficiency) Qualitative DetectionQualitative detection of Human Immunodeficiency virus type 1Real Time PCRPlasma, EDTA whole blood (3ml)1 dayThis test is intended for use in conjunction with clinical presentation and other laboratory markers of disease progress for the clinical management of HIV-1 infected patients. The test can be used to assess the baseline HIV-1 RNA level.
11HIV-1 Quantitative AnalysisQuantitative detection of Human Immunodeficiency virus type 1Real Time PCRPlasma, EDTA whole blood (3ml)1 dayThis test is intended for use in conjunction with clinical presentation and other laboratory markers of disease progress for the clinical management of HIV-1 infected patients. The test can be used to monitor the HIV-1 RNA level during the course of antiretroviral treatment.
12HIV-1 Analysis- COBAS TAQMANQuantitative detection of Human Immunodeficiency virus type 1 by COBAS TaqmanRT-PCR TAQMANPlasma, EDTA whole blood (3ml)1 dayThis test is highly sensitive and intended for use in conjunction with clinical presentation and other laboratory markers of disease progress for the clinical management of HIV-1 infected patients. The test can be used to monitor the HIV-1 RNA level during the course of antiretroviral treatment.
13HIV Drug Resistance and GenotypingAntiretroviral susceptibility information for protease inhibitors (PI) and reverse transcriptase inhibitors (NRTI, NNRTI)Sanger SequencingPlasma, EDTA whole blood (3ml)7 daysThis test helps in guiding the clinician for targeted therapy in the cases where patients are not responding towards the drugs.
14HIV Integrase Inhibitor Drug ResistanceAntiretroviral susceptibility information for integrase inhibitors (INI)Sanger SequencingEDTA whole blood (3ml)7 daysThis test helps in guiding the clinician for targeted therapy in the cases where patients are not responding towards the drugs.
15HIV Drug Resistance and Genotyping, ComprehensiveAntiretroviral susceptibility information for protease inhibitors (PI), reverse transcriptase inhibitors (NRTI, NNRTI) and integrase inhibitors (INI)Sanger SequencingEDTA whole blood (3ml)7 daysThis test helps in guiding the clinician for targeted therapy in the cases where patients are not responding towards the drugs.
16HIV-1 Pro-viral DNA Qualitative detectionQualitative detection of HIV1 provirusReal Time PCRCervical swab, Tissue Blocks1 dayHIV-1 proviral tests are recommended at 14 to 21 days, 1 to 2 months, and 4 to 6 months after birth, in infants born to HIV-1-infected mothers. Breastfeeding infants should be tested at baseline (1 to 2 days), 4 to 6 weeks, 3 months, and 4 to 6 months after birth. Two consecutive positive HIV-1 virologic test results (HIV-1 DNA and/or RNA) are necessary for confirming the diagnosis of HIV-1 infection in infants younger than 18 months of age.
17HPV (Human Papilloma Virus) Qualitative DetectionQualitative detection of Human Papilloma virus (HPV) 16&18Real Time PCRCervical swab, Tissue Blocks7 daysThe test is intended to detect high-risk HPV subtypes 16 and 18 to determine potential cancer risk
18HPV (Human Papilloma Virus) DNA DetectionGenotyping of HPV 16&18Sanger SequencingEDTA whole blood (3ml)1 dayDetects HPV in the specimen
19EBV (Epstein Barr Virus) Qualitative DetectionQualitative detection of Epstein Barr Virus (EBV)Real Time PCREDTA whole blood (3ml)1 dayEpstein-Barr virus (EBV) is the cause of a variety of disorders, including infectious mononucleosis (IM). Laboratory testing can help determine whether someone is susceptible to EBV infection or has a recent or past infection.
20EBV (Epstein Barr Virus) Quantitative AnalysisQuantitative detection of Epstein Barr Virus (EBV)Real Time PCREDTA whole blood (3ml)1 dayEpstein-Barr virus (EBV) is the cause of a variety of disorders, including infectious mononucleosis (IM). Laboratory testing can help determine whether someone is susceptible to EBV infection or has a recent or past infection.
21CMV (Cytomegalo Virus) DNA Qualitative DetectionQualitative detection of Human Cytomegalovirus (CMV)Real Time PCREDTA whole blood (3ml)1 dayCMV infection is of clinical significance primarily in pregnant women, newborn infants with possible congenital infection,
immunosuppressed transplant patients and immunocompromised individuals.
22CMV (Cytomegalo Virus) DNA Quantitative AnalysisQuantitative detection of Human Cytomegalovirus (CMV)Real Time PCRCSF, EDTA whole blood (3ml)1 dayCMV infection is of clinical significance primarily in pregnant women, newborn infants with possible congenital infection,
immunosuppressed transplant patients and immunocompromised individuals.
23HSV (Herpes Simplex Virus) I & II Qualitative DetectionQualitative detection of Herpes Simplex Virus 1&2Real Time PCREDTA whole blood (3ml)1 dayDNA testing is analytically more sensitive than culture, especially in patients with encephalitis or meningitis. DNA
testing may be useful in diagnosis of infection in neonates. Neonates who have been exposed to HSV can develop disseminated infection and encephalitis. Encephalitis is usually due to HSV I whereas meningitis is usually due to HSV II. DNA testing provides reliable means to define the type.
24Dengue Qualitative detectionQualitative detection of Dengue virusReal Time PCREDTA whole blood (3ml)1 dayThis test is intended to diagnose Dengue fever infection during the initial stage of infection, days 1-5 after onset of symptoms, which is able to detect dengue virus subtypes 1-4.
25Chikungunya Qualitative detectionQualitative detection of Chikungunya virusReal Time PCREDTA whole blood (3ml), Urine, Swab1 dayThis test is intended to diagnose chikungunya fever infection during the initial stage of infection.
26Chlamydia qualitative DetectionQualitative detection of Chlamydia trachomatisReal Time PCREDTA whole blood (3ml), Urine, Swab1 dayThis test is used to screen for the infections caused by the bacteria Chlamydia trachomatis.
27Neisseria Gonorrhoea Qualitative DetectionQualitative detection of Neisseria GonorrhoeaReal Time PCREDTA whole blood (3ml)1 dayThis test is used to screen for the infections caused by the Neisseria gonorrhoea
28Rubella Qualitative DetectionQualitative detection of Rubella virusReal Time PCRCSF, EDTA whole blood (3ml)1 dayFor the rapid diagnosis of congenital rubella virus infection.
29Japanese Encephalitis VirusQualitative detection of Japanese Encephalitis virusReal Time PCRCSF, EDTA whole blood (3ml)1 dayThis test is intended to identify JEV in the specimen
30Parvo Virus B 19 Qualitative DetectionQualitative detection of Parvo B19 virusReal Time PCRCSF, EDTA whole blood (3ml)1 dayDiagnose and monitor human parvovirus infection in patient with suppressed or delayed immune response.
31Toxoplasma Qualitative DetectionQualitative detection of Toxoplasma virusReal Time PCREDTA whole blood (3ml)1 dayConfirm toxoplasmosis infection in immunocompromised hosts as well as fetuses and newborns.
32Varicella Zoster Virus (VZV) Qualitative DetectionQualitative detection of VZVReal Time PCREDTA whole blood (3ml), AF, CVS1 dayThis test is intended to identify rapid idenfication of VZV in the specimen
33TORCH-PCR qualitative DetectionQualitative detection of Toxovirus, Rubella virus, CMV, HSVReal Time PCRCSF1 dayThese groups of infections are the main threats of serious congenital infection during pregnancy, which may ultimately cause fetal damage or other anomalies.
34Viral Encephalitis Panel Qualitative DetectionQualitative detection of HSV I&II, VZV, Enterovirus, mumps virus, Human parechovirusReal Time PCRCSF1 dayThis panel may assist in identifying important infectious agents causing encephalitis or meningoencephalitis.
35CSF- Viral Panel Qualitative DetectionQualitative detection of EBV, CMV, VZV, HSVI&II, JCReal Time PCREDTA whole blood (3ml), Urine1 dayThis panel may assist in identifying important infectious agents causing viral diseases
36BK Polyoma Virus Quantitative DetectionQualitative detection of BK polyoma virusReal Time PCREDTA whole blood (3ml), Urine, CSF1 dayThe presence of BKV DNA in blood reflects the dynamics of the disease: the conversion of plasma from negative to positive for BKV DNA after transplantation, the presence of DNA in plasma in conjunction with the persistence of nephropathy, and its disappearance from plasma after the reduction of immunosuppressive therapy. However, BKV DNA is typically detectable in urine prior to plasma and may serve as an indication of impending BKV associated nephropathy.
37JC Polyoma Virus Quantitative DetectionQualitative detection of JC polyoma virusReal Time PCREDTA whole blood (3ml), Urine, CSF1 dayDetection of JC virus (JCV) DNA supports the clinical diagnosis of progressive multifocal leukoencephalopathy (PML) due to JCV.
38Mycobacterium tuberculosis Qualitative DetectionQualitative detection of MTBReal Time PCREDTA whole blood (3ml), Urine, CSF, Swab, Tissue, FFPE Blocks, Body Fluids1 dayThis rapid PCR test detects MTB DNA from the specimen.
39Zika VirusQualitative detection of Zika virusReal Time PCRSerum, Urine1 dayProvides qualitative detection of Zika virus RNA from urine collected during the acute phase of infection.
40Influenza VirusQualitative detection of Influenza A, Influenza B, HINIReal Time PCRNasopharyngeal swab1 dayProvides qualitative detection of Influenza virus RNA.